Trace-amine associated receptor 1 (TAAR1) is the best-characterized member of the family of TAARs.TAAR1 is broadly expressed in the brain, especially within the monoaminergic systems.Evidence from electrophysiological and neurochemical studies evaluating the effects of genetic and pharmacological interventions on TAAR1 revealed that TAAR1 modulates
Cyanide is a potent toxic agent, and the few available antidotes are not amenable to rapid deployment in mass exposures.As a result, there are ongoing efforts to exploit different animal models to identify novel countermeasures.We have created a pipeline that combines high-throughput screening in zebrafish with subsequent validation in two mammalia
Building fabric retrofitting is an important first step in improving building energy efficiency.The United Kingdom’s (UK) housing stock is one of the most inefficient in Europe, and Northern Ireland has the second-highest level of fuel poverty in the UK.This Griller Simmerstat Northern Irish case study developed three fabric retrofit scenarios th
Abstract Background Researchers commonly analyze lists of differentially expressed entities (DEEs), such as differentially expressed genes (DEGs), differentially expressed proteins (DEPs), and differentially methylated positions/regions (DMPs/DMRs), across multiple pairwise comparisons.Large biological studies can involve multiple conditions, tissu